National Patient Safety Alert

There are limited supplies of pancreatic enzyme replacement therapies (PERT).

• Creon® 10,000 and 25,000 capsules are in limited supply until 2026
• Nutrizym® 22 capsules are out of stock until mid-August 2024
• Pancrex V® capsules and powder remain available but are unable to support an increase in demand.

This alert is for action by: All organisations involved in prescribing and dispensing pancreatic enzyme replacement therapy (PERT).

This is a safety critical and complex National Patient Safety Alert. Implementation should be co-ordinated by an executive lead (or equivalent role in organisations without executive boards) and supported by clinical leaders in community pharmacy, GP practices and clinical leaders in pharmacy, dietetics, respiratory, hepatobiliary and cancer services.

This alert supersedes the Medicine Supply Notification (MSN/2024/054) issued on 9 May 2024.

Further information and actions required can be found in the alert on the CAS website.