National Patient Safety Alert

A National Patient Safety Alert has been issued on the shortage of pancreatic enzyme replacement therapy (PERT). This alert contains actions which are in addition to those outlined in the National Patient Safety Alert (NatPSA/2024/007/DHSC) issued on 24 May 2024.

There are limited supplies of pancreatic enzyme replacement therapies (PERT). 

• Creon® 10,000 and 25,000 capsules remain in limited supply until 2026
• Nutrizym® 22 capsules and Pancrex V® capsules and powder are intermittently available but are unable to fully cover the gap in supply.

This National Patient Safety Alert provides further background, clinical information and actions for providers.